|
Symbol Name ID |
Prkg1
protein kinase, cGMP-dependent, type I MGI:108174 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Subarachnoid hemorrhage |
Bruising susceptibility |
Bicuspid aortic valve |
Cardiomegaly |
Ascending aortic dissection |
Aortic aneurysm |
Abdominal aortic aneurysm |
Thoracic aortic aneurysm |
Aortic root aneurysm |
Ascending tubular aorta aneurysm |
Descending thoracic aorta aneurysm |
Aortic dissection |
Descending aortic dissection |
Aortic rupture |
Mucoid extracellular matrix accumulation |
Patent ductus arteriosus |
Carotid artery dilatation |
Carotid artery stenosis |
Anterior cerebral artery stenosis |
Middle cerebral artery stenosis |
Posterior cerebral artery stenosis |
Dilatation of the cerebral artery |
Moyamoya phenomenon |
Coronary artery aneurysm |
Coronary artery atherosclerosis |
Premature coronary artery atherosclerosis |
Coronary artery dissection |
Peripheral arterial stenosis |
Cystic medial necrosis |
Stroke |
Ischemic stroke |
Transient ischemic attack |
Abnormal left ventricular function |
Aortic regurgitation |
Hypertension |
Hypovolemia |
Cutis marmorata |
Livedo reticularis |
| Disease(s) Associated with PRKG1 | ||||||||||||||||||||||||||||||||||||||
| thoracic aortic aneurysm |
| Mouse Phenotypes | cardiovascular system phenotype |
enlarged heart |
abnormal cardiac muscle contractility |
abnormal cardiac muscle relaxation |
abnormal systemic arterial blood pressure |
increased systemic arterial blood pressure |
hypertension |
salt-resistant hypertension |
increased mean systemic arterial blood pressure |
increased systemic arterial diastolic blood pressure |
increased systemic arterial systolic blood pressure |
abnormal blood vessel physiology |
abnormal vascular smooth muscle physiology |
decreased vasodilation |
|
| Availability | Mouse Genotype | ||||||||||||||
| Prkg1tm1Hfm/Prkg1tm1Hfm | |||||||||||||||
| Prkg1tm1Meme/Prkg1tm1Meme | |||||||||||||||
| Prkg1tm1Naw/Prkg1tm1Naw | |||||||||||||||
| Prkg1tm2.1Naw/Prkg1tm2.1Naw | |||||||||||||||
| Prkg1tm1b(KOMP)Wtsi/Prkg1+ | |||||||||||||||
| Myl7tm1(cre)Krc/Myl7+ Prkg1tm2Naw/Prkg1tm2Naw (conditional) |
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| Neurod6tm1(cre)Kan/Neurod6+ Prkg1tm2Naw/Prkg1tm2.1Naw (conditional) |
* | ||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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